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The rescheduled hydrocodone combination products coincided with a statistically significant increase in opioid trading through online US cryptomarkets. This increase was not observed for any other drug group or country. Opioid traders moved to more potent opioids, including oxycodone and fentanyl. The study ended on April 3 with 7,900 respondents. It is not clear how these changes will affect the future of the drug industry.


In 2014, the Drug Enforcement Administration (DEA) rescheduled oxycodone and hydrocodone combination products, allowing them to be traded on cryptomarkets. This change coincided with an increase in the illicit trading of opioids, including fentanyl and oxycodone, through US cryptomarkets. The DEA conducted an analysis of 31 of the largest cryptomarkets in October 2013 to July 2016. The main outcome measures included total transactions, advertised listings, active listings, and a number of illicit opioids.


Drug enforcement officials recently rescheduled opioids in the US and restricted their sale and trading on cryptomarkets. These developments coincided with an increase in illicit opioid trading in the US cryptomarkets. These trends were not observed for other drug groups or countries. The increase in illicit opioid trading was primarily driven by an increase in hydrocodone and other potent opioids, including oxycodone and fentanyl.

Since the schedule change on oxycodone products in October 2014, fentanyl has become the second-most popular product. In addition to oxycodone, fentanyl is also widely available in the cryptomarket. During the study, researchers analyzed data on 31 cryptomarkets, which operated from September 2013 to July 2016. According to the report, illicit opioids came from outside the US and within the US.